synthesis and cytotoxicity evaluation of some new 6-nitro derivatives of thiazole-containing 4-(3h)-quinazolinone

Synthesis and cytotoxicity evaluation of some new 6-nitro derivatives of thiazole-containing 4-(3H)-quinazolinone

Quinazolinones are a group of fused heterocyclic compounds which have valuable biological properties including cytotoxic, antibacterial and antifungal activities. Thiazole group-containing compounds have been also reported to have a wide range of biological activities such as antitumor, anti-inflammatory, analgesic and antibacterial effects. Due to valuable cytotoxic effects of both thiazole gr...

Synthesis of some new tricyclic 4(3H)-quinazolinone derivatives

Quinazolinones are interesting molecules with a wide range of biological activities. We prepared a number of quinazolinone derivatives by the condensation of 5-bromo- or 5-nitro-substituted anthranilic acids with chloro-acyl chlorides. Anthranilic acid derivatives were treated with either 3-chloro-propionyl chloride or 4-chloro-butyryl chloride to yield the corresponding N-acyl-anthranilic acid...

Synthesis of some new 2,3-disubstituted-4(3H)quinazolinone derivatives

Quinazolinones are interesting materials because of their valuable biological effects. In this study some new 2,3-disubstituted-4(3H)quinqzolinone derivatives were synthesized from anthranilic acid in six steps by introducing a new chiral center to the aliphatic side chain of the quinazolinone. In the last step, a single acylation on the hydrazine moiety afforded final compounds. The structures...

synthesis of some new 2,3-disubstituted-4(3h)quinazolinone derivatives

quinazolinones are interesting materials because of their valuable biological effects. in this study some new 2,3-disubstituted-4(3h)quinqzolinone derivatives were synthesized from anthranilic acid in six steps by introducing a new chiral center to the aliphatic side chain of the quinazolinone. in the last step, a single acylation on the hydrazine moiety afforded final compounds. the structures...

synthesis of some new tricyclic 4(3h)-quinazolinone derivatives

synthesis and antibacterial, antifungal and cytotoxic evaluation of some new 2,3-disubstituted 4(3h)-quinazolinone derivatives